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IRIS: time-structured manifold projections

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Computer Science > Machine Learning

arXiv:2605.30810 (cs)
[Submitted on 29 May 2026]

Title:IRIS: time-structured manifold projections

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Abstract:High-dimensional biomedical data, such as cell-by-gene matrices, are increasingly generated temporally. However, Manifold Learning algorithms, like t-SNE and UMAP, cannot incorporate time-ordering in their layouts, obfuscating the dynamics of cell types or other classes. As a solution, we present IRIS, a new Manifold Learning algorithm that structures layouts both chronologically and by manifold topology. IRIS can visualize a wide range of dynamic biomedical data, including scRNA-seq, comparative metagenomics, and literature.
Subjects: Machine Learning (cs.LG)
Cite as: arXiv:2605.30810 [cs.LG]
  (or arXiv:2605.30810v1 [cs.LG] for this version)
  https://doi.org/10.48550/arXiv.2605.30810
arXiv-issued DOI via DataCite (pending registration)

Submission history

From: Brian Ondov [view email]
[v1] Fri, 29 May 2026 03:57:08 UTC (14,876 KB)
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