Specialty-Specific Medical Language Model for Immune-Mediated Diseases
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Computer Science > Computation and Language
arXiv:2605.28838 (cs)
[Submitted on 12 Apr 2026]
Title:Specialty-Specific Medical Language Model for Immune-Mediated Diseases
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Abstract:Extracting detailed clinical information from free-text medical narratives remains a practical challenge for researchers and healthcare systems. Terminology for immune-mediated and infectious diseases is especially inconsistent across sources, which often limits the ability of general-purpose Natural Language Processing (NLP) systems to capture the relevant biomedical concepts with sufficient granularity. We developed a domain-specific Named Entity Recognition (NER) model tailored to identify disease-related entities occurring in immunology and infectious disease contexts. We assembled and manually annotated a dataset of 371 case reports in collaboration with two clinical specialists, defining twelve entity classes covering immune-mediated and infectious conditions as well as related symptoms and clinical descriptors. We evaluated several modeling strategies, including the MedicalNER architecture with multiple healthcare-specific embeddings, a BERT-based token classification model, and zero-shot NER systems. The strongest performance was obtained with a transformer-based model trained on clinical-domain embeddings, which reached an F1 score of 0.89, consistently outperforming baseline and zero-shot approaches. The combination of specialized embeddings and expert annotation proved particularly valuable for capturing nuanced disease terminology and improving generalization across heterogeneous biomedical text. The prompted LLM baseline achieved substantially lower performance under the same evaluation protocol, reflecting difficulties in producing span-consistent outputs for fine-grained entity boundaries despite detailed prompting. The resulting model provides a structured way to analyze case reports and can support downstream tasks such as cohort identification, disease monitoring, and clinical decision support.
| Comments: | 15 pages, 5 figures. Funded in part by NIAID/NIH under contract 75N93024C00010 |
| Subjects: | Computation and Language (cs.CL); Artificial Intelligence (cs.AI) |
| Cite as: | arXiv:2605.28838 [cs.CL] |
| (or arXiv:2605.28838v1 [cs.CL] for this version) | |
| https://doi.org/10.48550/arXiv.2605.28838
arXiv-issued DOI via DataCite
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