GraM-Diff: A Unified Graph-Mamba Diffusion Framework for EEG-Based Alzheimer's Disease Data Generation and Diagnosis
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Computer Science > Machine Learning
Title:GraM-Diff: A Unified Graph-Mamba Diffusion Framework for EEG-Based Alzheimer's Disease Data Generation and Diagnosis
Abstract:Electroencephalography (EEG) is a promising, non-invasive, and cost-effective modality for Alzheimer's disease (AD) detection, but deep learning methods are limited by small and imbalanced clinical datasets. Generative augmentation offers a solution, yet existing approaches rely on inefficient class-specific models or fail to capture complex spatial and temporal brain dynamics. To address this, we propose GraM-Diff, a unified classifier-guided Graph-Mamba diffusion framework for EEG synthesis. It embeds Graph Convolutional Networks within a diffusion U-Net to model inter-electrode connectivity and Bidirectional Mamba state-space blocks for linear-complexity long-range temporal modeling. Latent-space classifier guidance lets a single model generate both healthy and pathological EEG within a shared representation, avoiding fragmented per-cohort pipelines. Across four EEG-based AD benchmarks, synthetic augmentation improves classification, yields superior Context-FID and correlation scores over strong generative baselines, and enhances robustness in data-scarce settings.
| Subjects: | Machine Learning (cs.LG) |
| Cite as: | arXiv:2608.29755 [cs.LG] |
| (or arXiv:2608.29755v1 [cs.LG] for this version) | |
| https://doi.org/10.48550/arXiv.2608.29755
arXiv-issued DOI via DataCite (pending registration)
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| Journal reference: | MICCAI 2026 EMERGE |
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